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First published on April 10, 2008
American Journal of Hospice and Palliative Medicine® 2008, doi:10.1177/1049909108315518

Article

Cytokines and Cancer Anorexia Cachexia Syndrome

Nabila Bennani-Baiti, MD and Mellar P. Davis, MD, FCCP*

Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

* To whom correspondence should be addressed. E-mail: davism6{at}ccf.org.


  Abstract
Cancer anorexia cachexia syndrome is frequent yet still a not well understood cancer-related problem. The pathophysiology of cancer cachexia is multifactorial. It is suggested to be the result of tumor–host interactions and studies of the disturbances seen during cancer anorexia cachexia syndrome, such as anorexia, hypermetabolism, tissue wasting, metabolic abnormalities, and hormonal changes, all point to the involvement in one way or another of one key factor: cytokines. The purpose of this review is to summarize the latest developments in the field of cytokines and their role in cancer anorexia cachexia syndrome. The emphasis is on the role of cytokines in anorexia and tissue wasting.


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