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American Journal of Hospice and Palliative Medicine®
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*METHADONE
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*Pain
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Methadone-induced myoclonus in advanced cancer

Nabeel Sarhill, MD

Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

Mellar P. Davis, MD, FCCP

Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

Declan Walsh, MSc, FACP

Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

C. Nouneh, MD

Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites. A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. This has rarely been reported before in the literature. The pathophysiology and management of myoclonus are discussed.

Key Words: cancer • methadone • myoclonus • opioids • pain • palliative medicine • pharmacotherapy

American Journal of Hospice and Palliative Medicine®, Vol. 18, No. 1, 51-53 (2001)
DOI: 10.1177/104990910101800113
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