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American Journal of Hospice and Palliative Medicine®
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Marijuana in the management of amyotrophic lateral sclerosis

Gregory T. Carter, MD

Muscular Dystrophy Association (MDA), Neuromuscular Disease Clinic, Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington

Bill S. Rosen, MD

Muscular Dystrophy Association (MDA), Neuromuscular Disease Clinic, New Hope Rehabilitation Center, St. Vincent Health-Care, Billings, Montana

Marijuana has been proposed as treatment for a widening spectrum of medical conditions. Marijuana is a substance with many properties that may be applicable to the management of amyotrophic lateral sclerosis (ALS). These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. In areas where it is legal to do so, marijuana should be considered in the pharmacological management of ALS. Further investigation into the usefulness of marijuana in this setting is warranted.

Key Words: ALS • cannabidiol • cannabinoids • cannabinol • marijuana • symptom management

American Journal of Hospice and Palliative Medicine®, Vol. 18, No. 4, 264-270 (2001)
DOI: 10.1177/104990910101800411
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