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American Journal of Hospice and Palliative Medicine®, Vol. 20, No. 4, 297-306 (2003)
DOI: 10.1177/104990910302000413

Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population

Howard S. Smith, MD

Department of Anesthesiology, Pittsburgh, Pennsylvania

Whitney Baird, PharmD

Middletown, New York

This paper discusses the treatment of pain in the palliative care patient, specifically the use of meloxicam and recent advances in agents with cyclooxygenase-2 (COX-2) selectivity. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that preferentially inhibits COX-2 more than cyclooxygenase-1 (COX-1), especially at low doses, thereby offering advantages over traditional nonselective NSAIDs. New COX-2 selective agents are discussed, including valdecoxib, parecoxib, etoricoxib, and COX-189.

Key Words: COX-2 inhibitors • meloxicam • NSAIDs • palliative care • pain management


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