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American Journal of Hospice and Palliative Medicine®
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Changes in endocrine therapy: Anastrozole and advanced breast cancer in postmenopausal women

Jean-Marc Nabholtz, MD, MSc

Hartmann Oncology Institute, American Hospital of Paris, Paris, France

Emerging data on endocrine therapies necessitates a re-evaluation of treatment strategies for advanced breast cancer. In this review, we present data from recent studies of the third-generation, nonsteroidal aromatase inhibitor (AI) anastrozole that illustrate its changing role in the treatment of postmenopausual women with advanced breast cancer. These studies demonstrate that anastrozole is now a treatment of choice as first-line therapy for patients presenting with advanced breast cancer and for patients who have progressed to advanced disease after adjuvant therapy with tamoxifen. A further trial has also shown that anastrozole is an effective and well-tolerated alternative to tamoxifen as adjuvant treatment for postmenopausal women with early breast cancer.

Key Words: nonsteroidal aromatase inhibitor • breast cancer • anastrozole • tamoxifen

American Journal of Hospice and Palliative Medicine®, Vol. 21, No. 6, 457-465 (2004)
DOI: 10.1177/104990910402100612
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