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American Journal of Hospice and Palliative Medicine®
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Methadone

Shalini Chhabra, MD, MPH

Department of Medicine, East Tennessee State University, and Home-Based Primary Care, James H. Quillen Veterans Affairs Medical Center at Mountain Home, Johnson City, Tenessse, shalinichhabramd{at}yahoo.com

Janet Bull, MD, FAAHPM

Four Season's Hospice and Palliative Care, Hendersonville, North Carolina

Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing. It is critical when using the drug to monitor for signs and symptoms of toxicity so that overdosing or toxicity can be identified in a timely manner. This review discusses these important topics so that methadone can be used safely and effectively.

Key Words: pharmacodynamics • bioavailability • indications • equianalgesic dosing • methadone toxicity

American Journal of Hospice and Palliative Medicine®, Vol. 25, No. 2, 146-150 (2008)
DOI: 10.1177/1049909107312597
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 AM J HOSP PALLIAT CAREHome page
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Methadone Isomers and Their Role in Pain Management
American Journal of Hospice and Palliative Medicine, April 1, 2009; 26(2): 149 - 150.
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