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American Journal of Hospice and Palliative Medicine®
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Review Article: Cytokines and Cancer Anorexia Cachexia Syndrome

Nabila Bennani-Baiti, MD

Harry R. Horvitz Center for Palliative Medicine (a World Health Organization demonstration project in palliative medicine), Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

Mellar P. Davis, MD, FCCP

The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic, 9500 Euclid Avenue, Mailbox R35, Cleveland, OH 44195; e-mail: davism6{at}ccf.org

Cancer anorexia cachexia syndrome is frequent yet still a not well understood cancer-related problem. The pathophysiology of cancer cachexia is multifactorial. It is suggested to be the result of tumor—host interactions and studies of the disturbances seen during cancer anorexia cachexia syndrome, such as anorexia, hyper-metabolism, tissue wasting, metabolic abnormalities, and hormonal changes, all point to the involvement in one way or another of one key factor: cytokines. The purpose of this review is to summarize the latest developments in the field of cytokines and their role in cancer anorexia cachexia syndrome. The emphasis is on the role of cytokines in anorexia and tissue wasting.

Key Words: cancer • cytokines • cancer-related cachexia • anorexia • tissue wasting

This version was published on October 1, 2008

American Journal of Hospice and Palliative Medicine®, Vol. 25, No. 5, 407-411 (2008)
DOI: 10.1177/1049909108315518
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