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American Journal of Hospice and Palliative Medicine®
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*Pain
*Palliative Care
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Memantine (Namenda) for Neuropathic Pain

Mailien Rogers, DO

Department of Internal Medicine, ETSU College of Medicine, Johnson City, Tennessee

Atif Rasheed, MD

Department of Family Medicine ETSU College of Medicine, Johnson City, Tennessee

Abdolali Moradimehr, PharmD

University of Appalachia College of Pharmacy, Oakwood, Virginia

Steven J. Baumrucker, MD, FAAHPM

Department of Family Medicine, ETSU College of Medicine, Johnson City, Tennessee, Wellmont Health System, Kingsport, Tennessee, hospicedoc{at}charter.net

Neuropathic pain is common in the palliative care population; unless adequately treated, the pain can lead to chronic anxiety, depression, and social impairment. Many treatments have been proposed for neuropathic pain; however, it remains underdiagnosed, under-treated, and often requires long-term therapy with risk of adverse effects. Memantine (Namenda), an N-Methyl, D-aspartate receptor inhibitor currently marketed for the treatment of dementia, has been proposed as a medication for the treatment of neuropathic pain for its mechanism, safety, lack of serious adverse effects, and relatively rapid onset of action. However, clinical trials have not been promising so far and its routine use in neuropathic pain is not currently recommended.

Key Words: neuropathic pain • namenda • memantine • NMDA antagonist

American Journal of Hospice and Palliative Medicine®, Vol. 26, No. 1, 57-59 (2009)
DOI: 10.1177/1049909108330025
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