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American Journal of Hospice and Palliative Medicine®
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1049909108319267v1
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Article

Fatigue in Advanced Cancer: A Prospective Study

Katherine Hauser, MBBS, FRACGP, Declan Walsh, Msc FACP FRCP(Edin)*, Lisa A. Rybicki, MS, Mellar P. Davis, MD, FCCP, and Dilara Seyidova-Khoshknabi, MD

Harry R. Horvitz Center for Palliative Medicine

* To whom correspondence should be addressed. E-mail: walsht{at}ccf.org.


  Abstract
Fatigue is a common advanced cancer symptom. Clinical features are not well known. The authors surveyed consecutive patients admitted to a palliative medicine program to identify clinical correlates of fatigue. Data collected included age, sex, performance status, primary site, prior chemotherapy/radiation therapy, and blood transfusions. Visual analogue scales assessed fatigue, quality of life, and ability to perform daily activities. Weight change was estimated. Laboratory results including lactate dehydrogenase and hemoglobin were recorded. Fatigue severity was associated with brain metastases, poor performance status, poor quality of life, and reduced ability to perform activities. Prior radiation therapy was associated with less severe fatigue. Age, sex, and hemoglobin level were not associated with fatigue. Fatigue was universal on referral. Brain metastases and poor quality of life independently predicted severity. Hemoglobin level did not predict fatigue. Further studies are necessary to define the clinical features and relationships of fatigue.

First published on June 6, 2008, doi:10.1177/1049909108319267

American Journal of Hospice and Palliative Medicine® 2008;25:372.

A more recent version of this article appeared on October 1, 2008

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